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Custom Synthesis
Flexible Synthesis, Reliable Delivery, and Expert Support—Built for Your Research Needs
About Jennypeptide
Leading Expertise in Custom Peptide Synthesis
Jennypeptide specializes in high-quality peptide synthesis, with ongoing investment in R&D and advanced technology. We provide custom peptides of various lengths, sequences, and purity levels — supported by HPLC and MS data for full quality traceability.
Our production capabilities cover linear peptides and over 400 modification types, including fluorescent labels, cyclic peptides, stapled peptides, and phosphorylation. Proprietary synthesis methods allow us to handle complex sequences with high success rates.
With over 10,000 peptides in stock and 1,000+ catalog options, we serve pharmaceutical, cosmetic, and research clients worldwide. From small-scale to commercial production, we are committed to fast delivery, reliable quality, and technical excellence.
What We Offer
Custom Peptide Services: Linear, Modified, Multi-Scale, Multi-Purity
Why Choose Us
Unmatched Expertise in Custom Peptide Synthesis—From Quality to Speed
Every order includes MS and HPLC reports; optional peptide content, amino acid analysis, endotoxin reports, and solubility guidance available on request.
Typical lead time: 2–3 weeks. Need it sooner? We offer expedited delivery in as fast as 3 business days.
We synthesize peptides up to 180 amino acids. Our hybrid solid-liquid phase system helps solve even the most complex peptide sequences.
Over 400 available modifications—fluorescent tags, cyclization (disulfide/amide/bicyclic), isotope labeling, FRET pairs, AMC tags, and more.
With advanced QC and synthesis protocols, we achieve a >95% success rate across orders.
We protect your intellectual property. NDA agreements available for all projects upon request.
+0086 17737230080
Quality Assurance
We Follow Strict Standards to Ensure Every Peptide Meets Your Expectations
99.99% nitrogen atmosphere during synthesis minimizes side reactions and ensures reaction stability.
Each amino acid coupling is verified twice to ensure complete reaction and deprotection steps.
We use ultrapure DI water systems to improve peptide purity throughout the process.
Pre-freezing with liquid nitrogen preserves peptide structure and lyophilization quality.
Every synthesis step is documented—providing full traceability and continuous quality optimization.
Each batch is validated with mass spectrometry and HPLC to ensure final purity and identity.
Workflow
Custom Peptide Synthesis Workflow
From Order Placement to Quality Delivery – A Complete Production Flow
Delivery Support
We Provide Flexible Services to Meet Your Final Delivery Requirements
We offer electronic HPLC and MS reports, and can provide raw data upon request.
Solubility tests using standard solvents can be performed based on your specific needs.
Optional services include desalting and salt form conversion (e.g. to acetate), as requested.
We can divide your peptide into multiple aliquots in specified volumes or containers.
Common Questions
Frequently Asked Questions
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| Application Area | Recommended Purity |
| High-throughput Functional Screening | |
| Peptide microarrays | >70% and >75% |
| Antigen for antibody production | |
| Chromatography | |
| ELISA for antibody titer detection | |
| Immunoblotting (Semi-quantitative) | |
| Enzyme substrate peptides (semi-quantitative) | >80%, >85%, and >90% |
| Blocking peptides (semi-quantitative) | |
| Affinity purification | |
| Phosphorylation detection | |
| Protein electrophoresis and immunocytochemistry | |
| Standard ELISA and RIA (quantitative) | |
| Receptor–ligand interaction (quantitative) | |
| In vivo/in vitro bioassays | >95% |
| Enzyme research and inhibition experiments (quantitative) | |
| NMR studies | |
| Mass spectrometry analysis | |
| Other quantitative assays | |
| SAR Research | >98% |
| Clinical trials | |
| APIs (Active Pharmaceutical Ingredients) | |
| Industrial applications | |
| X-ray crystallography | |
Solubility depends on peptide polarity. Acidic peptides dissolve better in basic solutions and vice versa. Neutral/hydrophobic peptides may require organic solvents like DMSO, DMF, acetic acid, or methanol before dilution in water.
Peptides containing Met or Cys should not be dissolved in DMSO due to oxidation risk.
Solubility Testing: Always perform a small-scale solubility test using various solvents. Sonication may help but can cause heat-induced degradation.
Basic residues: K, R, H, N-terminus → dissolve in acidic solution
Acidic residues: D, E, C-terminus → dissolve in basic solution
Neutral/polar: G, A, S, T, C, N, Q, P, Acetyl, Amide groups
Hydrophobic: F, I, L, M, V, W, Y
Charge-based tips:
Assign +1 to basic residues (K, R, H, NH2 terminus), -1 to acidic (D, E, COOH terminus), and calculate net charge.
If net positive → basic peptide → try water, then 10-25% acetic acid, or TFA for solubilization.
If net negative → acidic peptide → use PBS or basic buffers like ammonium bicarbonate. Avoid oxidation above pH 7.
Neutral peptides → dissolve in organic solvents like acetonitrile, methanol, or DMF.
Note: Avoid freeze-thaw cycles. Store as lyophilized powder at -20°C (better -80°C). For solutions, use sterile water and filter when necessary.
Depends on your research model:
In vivo: Near-infrared dyes like ICG, Cy5.5, Nile Blue (650–900 nm) for deep tissue penetration.
In vitro: Dyes like AMC, FITC, TAMRA (400–600 nm) are more common.
Example: Cy5.5-labeled cMBP peptides targeting c-Met receptors in U87MG tumor cells showed high cellular uptake at nanomolar levels.
Main causes include:
Deamidation (Asn/Gln → Asp/Glu)
Oxidation (Met, Cys, His, Trp, Tyr)
Hydrolysis (especially Asp-Pro, Asp-Gly)
Incorrect disulfide bonds due to thiol exchange
Racemization (Asp most prone under alkaline pH)
β-Elimination (Cys, Ser, Thr)
Denaturation & Aggregation caused by structure loss during storage
All lyophilized peptide products can be shipped at room temperature protected from light and can be stored at room temperature for a few days or less than one week without significant degradation. However, for long-term storage, all lyophilized peptides must be kept in a dry and low-temperature environment, preferably at -20°C. If conditions allow, storage below -80°C is recommended. Under these conditions, most peptides remain stable for 1–2 years.
When using peptide products, allow the vial to reach room temperature before opening it. For peptides stored at -20°C, this process may take an hour or longer, depending on the package size. If the vial is opened while still cold, moisture can condense inside, leading to peptide degradation. Once opened, weigh the required amount quickly and seal the vial immediately to prevent moisture absorption—especially important for hydrophilic peptides.
Peptides containing residues such as Cys, Met, and Trp (prone to oxidation), or Gln, Asn, and Asp (prone to degradation), should not undergo repeated freeze-thaw cycles. To prevent oxidation or degradation, these peptides should be aliquoted into small portions. Only thaw what is needed, and discard any unused remainder.
Peptides that are not in immediate use should not be stored in solution form—even at -80°C.
Jennypeptide delivers peptides as lyophilized powders, optionally aliquoted as per customer request. Shipments are protected with ice packs or dry ice for sensitive peptides.
Standard documentation includes MS and HPLC analysis. Additional reports such as solubility tests and endotoxin data are available upon request.
Default is TFA salt. Other options include acetate, hydrochloride, ammonium, sodium, pamoate, and citrate salts.
TFA: Common but cytotoxic — avoid for cell assays.
Acetate: Low toxicity, widely used in cosmetic and pharmaceutical peptides.
Hydrochloride: Rare, specific to certain sequences.
Ammonium/Sodium: Use only when required due to solubility/stability impact.
Pamoate: Suitable for sustained-release formulations.
Citrate: Low toxicity, but custom development needed due to complex processing.
Site-directed mutation: Replace unstable residues.
Chemical modifications: PEGylation improves solubility, half-life, and protease resistance.
Stabilizing additives: Sugars, polyols, amino acids, and surfactants (Tween, Pluronic) prevent aggregation.
Lyophilization: Reduces water, minimizes degradation, and increases thermal stability.
